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Advanced Clinical Pathway

Hematologic cancers & cell therapy

Chinese reference name: 血液肿瘤与细胞治疗

Verified cellular immunotherapy (CAR-T) and complex allogeneic hematopoietic transplantation pathways for relapsed or refractory hematologic malignancies in top Chinese tertiary centers.

Patient Candidacy & Fast Facts

Key Considerations for Patients

Suitable Conditions: Advanced or recurrent cases seeking breakthrough therapies approved in top clinical centers.
National Centers: Direct pathways across 4 leading tertiary hospitals with dedicated international wings.
Pre-Travel Review: Multidisciplinary team (MDT) case review available before international travel.
Evaluation Window
1–2 Weeks
Language Support
English Dedicated

Explore Related Clinical Specialties

Begin with Hematology, then compare the support departments that can affect diagnosis, intervention, and recovery planning.

Start: HematologyPathologyCritical care medicinePediatric medicineOncology

These links organize research only. They do not diagnose, refer, or confirm current case acceptance.

Personalized Treatment Planning

BCMA & CD19 CAR-T Cellular Immunotherapy Pathway

Benchmark your condition, review clinical records needed for triage, and prepare your medical travel plan with leading centers.

Pioneering dual-target CAR-T constructs & commercial approvals in China
Dedicated hematologic ICU for CRS & neurotoxicity monitoring
Over 60% lower overall therapy cost vs Western commercial products
Pre-trip record checklistRequired for triage
  • Bone marrow biopsy & cytogenetics/FISH
  • Flow cytometry immunophenotyping report
  • Prior systemic lines of therapy summary
Build CAR-T & Hematology Plan

Pre-selects Ruijin Hospital, Shanghai Jiao Tong University & relevant clinical criteria

Specialized Treatment Protocols

Target Indications & Qualified Hospital Capabilities

Explore clinical indications, treatment modalities, bed and ICU requirements, and patient eligibility criteria verified across leading tertiary centers.

6 Priority Pathways Verified
High-Priority Target#01

Relapsed or Refractory Multiple Myeloma

复发/难治多发性骨髓瘤

Target Stage & Goal: For patients with multiple myeloma who have progressed after ≥3 lines of prior therapy (including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 antibody). Goal: Deep MRD-negative molecular remission.

Hospitals with Verified Conditions to Treat This Disease:
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
上海交通大学医学院附属瑞金医院Shanghai · Grade 3A Public (National Medical Center for Metabolic & Hematologic Diseases)
Department of Hematology / International Medical Services (VIP Clinic)
Hospital Facilities & Qualified Conditions:

Class-10,000 sterile laminar-flow transplant wards (35+ beds), specialized leukapheresis lab, 24/7 dedicated Hematology ICU for rapid CRS/ICANS emergency rescue, national GMP-grade cell preparation qualification.

Specific Treatment & Technology Offered:

Equecabtagene Autoleucel (伊基奥仑赛 BCMA CAR-T, Fucaso) & Autologous Stem Cell Rescue.

Required Patient Eligibility Criteria:

Diagnosed RRMM after ≥3 prior lines; ECOG 0-1; absolute lymphocyte count ≥0.5×10^9/L; CrCl ≥40 mL/min; LVEF ≥45%; no active uncontrolled systemic infection.

Peking Union Medical College Hospital
北京协和医院Beijing · Grade 3A Public (National Center for Difficult & Complicated Diseases)
International Medical Services (IMS) / Hematology Division
Hospital Facilities & Qualified Conditions:

National Rare Diseases Diagnosis and Treatment Network Lead Center, specialized plasma-cell disorder MDT board, high-resolution immunofixation and mass spectrometry laboratories.

Specific Treatment & Technology Offered:

Novel dual-target BCMA/CD19 sequential CAR-T protocols & salvage alkylator-free bridging regimens.

Required Patient Eligibility Criteria:

Documented extramedullary relapse, high-risk cytogenetics (del(17p), t(4;14), 1q21 amp); adequate bone marrow cellularity for apheresis.

High-Priority Target#02

Relapsed or Refractory Diffuse Large B-cell Lymphoma

复发/难治弥漫大B细胞淋巴瘤

Target Stage & Goal: Aggressive CD19+ B-cell lymphoma refractory to first-line R-CHOP or relapsed within 12 months post-autologous stem cell transplantation.

Hospitals with Verified Conditions to Treat This Disease:
Ruijin Hospital
上海瑞金医院Shanghai · Grade 3A Public (National Hematology Reference Center)
Lymphoma Center / International Medical Services
Hospital Facilities & Qualified Conditions:

Designated commercial infusion center for both Axi-cel and Relma-cel; full-process electronic tracking from vein-to-vein; dedicated cellular therapy clinical coordinator.

Specific Treatment & Technology Offered:

Relmacabtagene Autoleucel (瑞基奥仑赛 Carteyva) & Axicabtagene Ciloleucel (阿基仑赛 Yescarta).

Required Patient Eligibility Criteria:

Histologically verified CD19+ DLBCL, primary refractory or progressed after ≥2 lines of systemic chemoimmunotherapy; ECOG 0-1.

Shanghai Jiahui International Hospital
上海嘉会国际医院Shanghai · JCI-Accredited International Hospital (Strategic Collaboration with Massachusetts General Hospital Cancer Center)
Jiahui International Cancer Center (JICC) International Office
Hospital Facilities & Qualified Conditions:

Full-time bilingual oncologists and hematologists, dedicated single-patient HEPA-filtered cell therapy inpatient floor, direct international commercial insurance direct billing, overseas medical visa invitation support.

Specific Treatment & Technology Offered:

Commercial CD19 CAR-T Infusion Fast-Track & Autologous Stem Cell Mobilization.

Required Patient Eligibility Criteria:

Overseas or bilingual patients with CD19+ high-grade B-cell lymphoma; stable cardiopulmonary function; manageable tumor burden suitable for fludarabine/cyclophosphamide lymphodepletion.

High-Priority Target#03

Acute Lymphoblastic Leukemia in Relapse

复发/难治急性淋巴细胞白血病

Target Stage & Goal: B-cell acute lymphoblastic leukemia (B-ALL) with morphologic relapse or persistent minimal residual disease (MRD+ ≥0.01%) post-consolidation.

Hospitals with Verified Conditions to Treat This Disease:
Ruijin Hospital & Shanghai Children's Medical Center
SCMCShanghai · National Children's Medical Center & National Hematology Center
Department of Hematology / Stem Cell Transplant Center
Hospital Facilities & Qualified Conditions:

Ultra-sensitive 10-color flow cytometry minimal residual disease (MRD) detection lab (sensitivity 10^-5), Class-100 sterile isolation transplant rooms, bridging haploidentical transplantation pipeline.

Specific Treatment & Technology Offered:

CD19 / CD22 targeted CAR-T cell infusion followed by consolidative allogeneic hematopoietic stem cell transplantation (Allo-HSCT).

Required Patient Eligibility Criteria:

Relapsed/refractory B-cell ALL; bone marrow blast count <30% before lymphodepletion; adequate organ reserve; no severe active GVHD.

Specialized Indication#04

Acute Myeloid Leukemia & High-Risk MDS

急性髓系白血病与高危MDS

Target Stage & Goal: Unfavorable-risk cytogenetic/molecular AML (FLT3-ITD, TP53, complex karyotype) or induction failure requiring targeted therapy and immediate transplantation.

Hospitals with Verified Conditions to Treat This Disease:
Ruijin Hospital
上海交通大学医学院附属瑞金医院Shanghai · Grade 3A Public (State Key Laboratory of Medical Genomics)
Myeloid Disease Team / International Medical Center
Hospital Facilities & Qualified Conditions:

NGS-based comprehensive 100+ gene myeloid mutation profiling (FLT3-ITD/TKD, NPM1, IDH1/2, TP53), Asia's largest haploidentical transplant database.

Specific Treatment & Technology Offered:

Precision targeted regimens (Venetoclax + Azacitidine, Gilteritinib) combined with haploidentical or matched unrelated Allo-HSCT.

Required Patient Eligibility Criteria:

High-risk cytogenetic/molecular AML or induction failure; patient age <70; HCT-CI ≤3; documented absence of active fungal infection.

Specialized Indication#05

Complex Allogeneic Hematopoietic Stem Cell Transplantation

复杂异基因造血干细胞移植

Target Stage & Goal: Severe hematologic diseases requiring allogeneic stem cell reconstitution with haploidentical family donors or cord blood bridging.

Hospitals with Verified Conditions to Treat This Disease:
Ruijin Hospital & Peking Union Medical College Hospital
Shanghai / Beijing · Grade 3A Public (National Medical Centers)
Blood & Marrow Transplantation Division
Hospital Facilities & Qualified Conditions:

50+ continuous positive-pressure HEPA laminar airflow transplant rooms, specialized post-transplant infection isolation unit, advanced extracorporeal photopheresis (ECP) for refractory GVHD.

Specific Treatment & Technology Offered:

Modified Beijing Protocol Haploidentical Transplantation, matched unrelated donor (MUD) transplant, and cord blood salvage transplantation.

Required Patient Eligibility Criteria:

High-risk hematologic malignancy in complete remission; HLA-typing completed for patient and potential family donors; negative viral screen for active hepatitis/HIV.

Specialized Indication#06

Target-Specific Solid Tumor CAR-T

CLDN18.2 Advanced Gastric / GEJ Adenocarcinoma

Target Stage & Goal: Metastatic gastric or gastroesophageal junction adenocarcinoma with confirmed CLDN18.2 overexpression after failure of standard chemotherapy.

Hospitals with Verified Conditions to Treat This Disease:
Shanghai Jiahui International Hospital & Ruijin Hospital
Shanghai · JCI International Hospital & National Public Center
Gastrointestinal Oncology Center / Clinical Trials Office
Hospital Facilities & Qualified Conditions:

Standardized IHC 28-8 CLDN18.2 pathology testing lab, dedicated gastrointestinal oncology multidisciplinary team, intensive monitoring protocol for delayed mucosal and systemic toxicities.

Specific Treatment & Technology Offered:

Satricabtagene Autoleucel (CT041 / CLDN18.2-targeted CAR-T) under strict clinical pathway.

Required Patient Eligibility Criteria:

Histologically confirmed advanced gastric/GEJ adenocarcinoma; positive CLDN18.2 expression (≥2+ in ≥40% cells); failed ≥2 prior lines; no bowel obstruction or massive ascites.

When This Option May Not Be Suitable

Situations Requiring Immediate Local Care or Where Travel Is Not Advised

Please evaluate these critical clinical exclusions before initiating cross-border medical consultations.

  • The patient is medically unstable or experiencing rapidly progressing organ failure.
  • Safe bridging therapy or prolonged hematology follow-up cannot be arranged.
  • CAR-T is sought as a universal panacea without a verified molecular target and approved indication.
Clinical Capabilities & Approvals

Key Clinical Milestones & Regulatory Status

Documented regulatory approvals, published clinical evidence, and capability standards verified across leading medical centers.

01

Verified capability

Equecabtagene autoleucel (BCMA CAR-T) received official approval in China for adults with relapsed/refractory multiple myeloma after ≥3 prior lines.

S01

02

Verified capability

China has the world's largest and most active cell therapy trial landscape, with standardized clinical pathways across designated Grade 3A teaching centers.

S02

03

Verified international access

Official patient dossiers document international patient admission and successful CAR-T cell manufacturing at Ruijin Hospital and Jiahui International.

S03S25S37
Qualified Hospital Directory

Leading Tertiary Centers & Advanced Offerings

Hospitals verified for clinical capability, advanced technology access, and international patient coordination pathways.

01

Institution in research

Ruijin Hospital (上海交通大学医学院附属瑞金医院)

S03S37

Documented capability

Leading national hematology center with full-cycle cell therapy manufacturing, infusion, ICU escalation, and bone marrow transplantation.

International access

Verified international medical department (VIP Clinic) supporting English medical records review, case coordinator, and hospital deposit procedures.

Current editorial status

Direct medical intake available. Requires pre-travel submission of complete pathology slides, bone marrow flow cytometry, and prior regimen logs.

View hospital details
Specific Advanced Treatments & Technologies Offered:
Cell TherapyNMPA Approved Commercial
BCMA CAR-T Therapy (Equecabtagene Autoleucel / 伊基奥仑赛)
Target Indication:

Relapsed or refractory multiple myeloma (≥3 prior lines)

Clinical Feature: NMPA approved commercial product, 96% overall response rate, full-trajectory CRS/ICANS ICU monitoring.

Cell TherapyNMPA Approved Commercial
CD19 CAR-T Therapy (Relma-cel / 瑞基奥仑赛 & Axi-cel / 阿基仑赛)
Target Indication:

Relapsed/refractory large B-cell lymphoma (DLBCL) & follicular lymphoma

Clinical Feature: Designated infusion center with standardized leukapheresis, bridging chemotherapy, and long-term follow-up.

Complex Surgery & TransplantNational Reference Center
Haploidentical & Matched Allogeneic Stem Cell Transplant (Allo-HSCT)
Target Indication:

High-risk acute myeloid leukemia (AML) & acute lymphoblastic leukemia (ALL)

Clinical Feature: Advanced sterile laminar flow transplant ward cluster with specialized GVHD prevention and control protocols.

02

Institution in research

Shanghai Jiahui International Hospital (上海嘉会国际医院)

S23S25S36

Documented capability

Comprehensive international oncology and cell therapy center with bilingual care teams and direct commercial insurance billing.

International access

Publicly verified direct international office (+852 4619 1904 / internationaloffice@jiahui.com) with remote multidisciplinary tumor board review.

Current editorial status

Active intake for international patients. Provides itemized formal medical quotes and medical visa assistance.

View hospital details
Specific Advanced Treatments & Technologies Offered:
Cell TherapyNMPA Approved Commercial
Commercial CAR-T Infusion Fast-Track (Yescarta / Axicabtagene Ciloleucel)
Target Indication:

Relapsed or refractory diffuse large B-cell lymphoma (DLBCL)

Clinical Feature: Dedicated international inpatient floor, full-time English-speaking hematologists, overseas medical visa invitation letters.

Complex Surgery & TransplantRoutine Clinical Center
Autologous Stem Cell Transplantation (Auto-HSCT)
Target Indication:

High-dose consolidation for multiple myeloma and sensitive lymphomas

Clinical Feature: Class-100 clean ward environment with comprehensive supportive care and cross-border continuity planning.

03

Institution in research

Peking Union Medical College Hospital (北京协和医院)

S16

Documented capability

National benchmark for complex and rare hematologic diseases, systemic clonal disorders, and multiorgan involvement.

International access

English-speaking International Medical Services (IMS) provides outpatient appointments, inpatient care, and remote second opinions.

Current editorial status

Intake through International Medical Services. High case-complexity threshold; requires comprehensive prior diagnostics in English.

View hospital details
Specific Advanced Treatments & Technologies Offered:
Precision Targeted & BiologicsNational Reference Center
Precision Targeted & Multi-Agent Immunotherapy Regimens
Target Indication:

Castleman disease, primary CNS lymphoma, refractory plasma cell disorders

Clinical Feature: National Rare Diseases Diagnosis and Treatment Network lead institution; comprehensive multidisciplinary diagnosis (MDT).

Precision Targeted & BiologicsLeading Center Technique
Ultra-Sensitive Minimal Residual Disease (MRD) Clearance Protocols
Target Indication:

Acute leukemias and residual disease eradication planning

Clinical Feature: High-dimensional 10-color flow cytometry and high-throughput NGS deep clonal tracking.

04

Institution in research

Shanghai SinoUnited Hospital (上海非公立国际中心 - 联动公立三甲)

S19S38

Documented capability

Specialized outpatient screening, remote case triaging, and bidirectional transfer partnership with top public hematology wards.

International access

Direct international concierge (+86 400 186 2116 / internationalcare@suh.cn) providing multilingual communication.

Current editorial status

Recommended as an international screening entry point for patients needing translation and liaison with public hospital specialists.

View hospital details
Specific Advanced Treatments & Technologies Offered:
Cell TherapyCoordinated Access Pathway
Pre-CAR-T Evaluation & Public-Private Bidirectional Referral
Target Indication:

International patients seeking cell therapy candidacy assessment in China

Clinical Feature: Bilingual oncologist first-opinion, digital DICOM / pathology forwarding to tertiary hospital professors.

Verified Public Intake Channels

Hospital Intake & Consultation Channels

Contact first, transmit identifiable medical records only through authorized hospital coordination desks.

3 Verified Hospital Channels

Ruijin Hospital International Medical Center

S37
Channel:vip@rjh.com.cn · +86 21 64678970
Known Use
Direct patient inquiry, medical records pre-evaluation, and VIP admission coordination
Patient Intake Advisory
Requires digital transmission of English or translated medical records prior to scheduling.

Shanghai Jiahui International Cancer Center

S23S25
Channel:internationaloffice@jiahui.com · WhatsApp +852 4619 1904
Known Use
Remote bilingual consultation, international insurance pre-authorization, and medical visa facilitation
Patient Intake Advisory
Direct billing available for major global insurers; itemized estimate provided post-review.

Shanghai SinoUnited Hospital

S38
Channel:internationalcare@suh.cn · +86 400 186 2116
Known Use
Outpatient second opinion, bilingual case coordination, and tertiary hospital liaison
Patient Intake Advisory
Provides pre-travel screening and records forwarding to public hospital specialists.
Medical Documentation Checklist

Essential Records to Prepare for Clinical Review

Having translated clinical records organized accelerates multidisciplinary evaluation and enables accurate treatment feasibility confirmation.

7 Required Clinical Documents
01

Original pathology paraffin blocks or high-resolution digital slide scans

02

Bone marrow biopsy morphology, 10-color flow cytometry, cytogenetic FISH, and NGS panel reports

03

Chronological log of all prior lines: drug regimens, exact dosages, duration, best response, and resistance reasons

04

Whole-body PET-CT or contrast CT/MRI within the last 30 days (original DICOM disc files)

05

Organ baseline reserve: Complete blood count, liver/renal panel, coagulation, cardiac echocardiogram (LVEF), and pulmonary PFT

06

Infectious disease screen: Quantitative HBV DNA, HCV RNA, HIV, CMV, and EBV PCR titers

07

Performance status documentation: ECOG score and home-country hematologist referral letter

Cost Breakdown & Financial Guidance

Transparent Breakdown of Treatment Stages & Cost Benchmarks

Documented Overall Cost Range & Benchmarks

Commercial CAR-T product cost in China is approximately 990,000 to 1,200,000 RMB. Total pathway cost including hospital stay, lymphodepletion, and CRS management typically ranges from 1.2M to 1.5M RMB in public centers, higher in private international hospitals.

Important Financial Notice

Product drug price must not be confused with the total medical pathway cost. Complications, prolonged cytopenia, ICU care, and blood products will add to the final hospital bill.

Stage 1: Pre-Admission Clinical Workup & Apheresis

Scope: Comprehensive multidisciplinary tumor board review, bone marrow flow cytometry/MRD re-testing, baseline organ workup, leukapheresis machine run, and outpatient bridging medication.

Financial Notes: Typically self-funded deposit or covered by international private health insurance; varies if bridging chemotherapy is needed.

Stage 2: Cell Product Manufacturing & Procurement

Scope: Commercial CAR-T pharmaceutical purchase (e.g. Equecabtagene Autoleucel / Relmacabtagene Autoleucel) or trial-protocol cell laboratory production.

Financial Notes: Fixed commercial manufacturer price in China (approx. 990,000 - 1,200,000 RMB for commercial products); separate from hospital clinical services.

Stage 3: Inpatient Infusion, CRS Monitoring & ICU Contingency

Scope: Flu/Cy lymphodepleting chemotherapy, sterile laminar ward stay (typically 14-21 days), daily IL-6/cytokine tracking, tocilizumab/steroid CRS intervention, and potential ICU escalation.

Financial Notes: Variable depending on the severity of Cytokine Release Syndrome (CRS) or neurotoxicity (ICANS); patients must reserve an ICU safety buffer.

Stage 4: Post-Discharge Local Follow-up & Home Care Transition

Scope: Day-30 and Day-90 bone marrow and PET-CT evaluations, immunoglobulin replacement infusions, antiviral prophylaxis, and formal English discharge summary translation.

Financial Notes: Outpatient visits and imaging; long-term infection monitoring transitions to the patient's home-country hematologist.

Cross-Border Travel & Continuity of Care

Travel Logistics, Hospital Stay & Long-Term Follow-up

Essential travel considerations, hospital stay durations, and follow-up safety protocols verified for international patients.

Pre-Travel & Inpatient

Before & During Travel

  • Cell manufacturing typically requires 2 to 4 weeks, during which the patient must remain clinically stable under bridging therapy.
  • Patients must maintain valid visa status (S2 medical visa) for at least 60-90 days from leukapheresis to post-infusion day 30.
  • A qualified home-country hematology center must agree in advance to provide post-discharge cytopenia and infection management.
Post-Discharge Care

Follow-Up Requirements

  • Weekly complete blood count and infection surveillance for the first 8 weeks post-discharge
  • Intravenous immunoglobulin (IVIG) supplementation for persistent hypogammaglobulinemia
  • Day 30, Day 90, and Month 6 bone marrow aspiration and whole-body PET-CT response assessments
Safety Alert Triggers

Urgent Local-Care Triggers

  • Temperature ≥38.5°C or signs of sepsis / neutropenic fever
  • Sudden onset of dyspnea, hypotension, or confusion (suggestive of delayed CRS or ICANS)
  • Severe spontaneous bleeding or sudden hemoglobin / platelet drops
Ready to Take the Next Step?

Build Your Personalized Medical Travel Plan

Treatment-specific eligibility, product availability, complication capacity, total pathway cost, and cross-border follow-up Our planning engine benchmarks your medical records, outlines expected cost ranges, and prepares pre-travel intake questions for hospital international desks.

Build CAR-T & Hematology PlanBrowse All Qualified Hospitals
Clinical & Safety Boundaries

This overview is for medical planning and hospital matching. It does not replace individualized diagnosis by treating specialists. Final treatment plans, drug indications, and quotes must be issued directly by the admitting hospital.

Emergency Notice: Acute deterioration, unstable vital signs, or active severe infections require immediate local emergency care without delay.