Complex or recurrent cancers
Specialized particle radiotherapy (carbon-ion & proton), high-complexity salvage surgery, and indication-specific immunotherapy for recurrent, refractory, or unresectable solid tumors.
Leading Hospital Centers & Specific Treatments Offered
Research notes on Chinese tertiary hospitals, specific advanced modalities, target indications, and international patient pathways
- Shanghai Proton and Heavy Ion Centernot in our hospital directory
- Fudan University Shanghai Cancer Centernot in our hospital directory
- Ruijin Hospitalnot in our hospital directory
A missing entry means our hospital directory does not cover that facility yet; it is not a statement about the facility's clinical capability.
Shanghai Proton and Heavy Ion Center (上海市质子重离子医院)
Carbon-Ion Precise Particle Therapy (碳离子重离子精准放疗)
Recurrent nasopharyngeal carcinoma, skull-base chordoma, localized prostate cancer, soft tissue sarcomas
Clinical Feature: High linear energy transfer (LET) heavy particles with sharp Bragg peak; superior cell-killing effect on hypoxic radioresistant tumors.
Proton Beam Pencil-Scanning Radiotherapy (质子笔形束扫描放疗)
Pediatric CNS tumors, chordomas, head-and-neck malignancies adjacent to critical neural pathways
Clinical Feature: Zero exit-dose sparing surrounding normal tissue, preserving cognitive and endocrine functions in adjacent structures.
Official English consultation channel (sphicvip@sphic.org.cn) supporting remote DICOM image prescreening and itemized particle therapy quotes.
Active international intake. Requires pre-arrival submission of all previous photon radiation dose distribution plans and contrast MRI/PET-CT.
Fudan University Shanghai Cancer Center (复旦大学附属肿瘤医院)
Complex Head & Neck Endoscopic Skull-Base Surgery
Locally recurrent nasopharyngeal carcinoma, sinus malignancies, salivary-gland cancers
Clinical Feature: Intraoperative robotic navigation, high-definition endoscope, carotid artery balloon occlusion assessment.
Da Vinci Xi Robotic Radical Pelvic and Retroperitoneal Dissection
Recurrent pelvic tumors, retroperitoneal liposarcomas, complex colorectal recurrences
Clinical Feature: High-precision nerve-sparing microdissection with multi-organ en-bloc resections.
International Medical Department coordinates English record intake, MDT panel review, and priority hospital admission.
Direct medical intake for international complex-surgery candidates. High surgical complexity threshold.
Target Disease Indications & Qualified Hospital Finder (5)
Which Chinese tertiary hospitals are noted for the beds, ICU support, and technologies each condition typically needs
Locally Recurrent Nasopharyngeal Carcinoma (NPC) & Skull Base Tumors (复发鼻咽癌与颅底脊索瘤)
Target Stage & Goal: Local recurrence of nasopharyngeal carcinoma after prior radical photon radiotherapy, or unresectable skull-base chordoma/chondrosarcoma adjacent to critical neurovascular structures.
Shanghai Proton and Heavy Ion Center (SPHIC / 上海市质子重离子医院)
Shanghai · Premier Carbon-Ion & Proton Radiotherapy FacilitySiemens synchrotron particle accelerator delivering carbon ions and protons, sub-millimeter 3D pencil-beam scanning, 6-degree-of-freedom robotic treatment couches, real-time 4D CT motion tracking.
Carbon-Ion Re-Irradiation (高相对生物有效性碳离子线二次放疗，精准破坏癌细胞双链DNA且周围危及器官受量急剧下降).
Confirmed localized recurrence or unresectable skull base tumor; interval from previous radiation >1 year; tumor distance to brainstem/optic chiasm >3 mm; KPS performance score ≥70; no distant metastases.
Fudan University Shanghai Cancer Center (FUSCC / 复旦大学附属肿瘤医院)
Shanghai · National Cancer Clinical Medical CenterWorld-renowned head and neck surgical oncology division, high-definition endoscopic skull base surgery theater, multi-modality tumor board.
Transnasal Endoscopic Skull Base Salvage Resection + Intraoperative Navigation.
Resectable recurrence without circumferential internal carotid artery encasement; patient able to tolerate general endotracheal anesthesia.
Locally Advanced / Unresectable Hepatocellular Carcinoma (局部晚期原发性肝癌)
Target Stage & Goal: Large solitary or multi-nodular hepatocellular carcinoma not amenable to curative open resection due to insufficient future liver remnant or microvascular invasion.
Shanghai Proton and Heavy Ion Center (SPHIC)
Shanghai · Particle Radiotherapy BenchmarkAdvanced respiratory gating system, implanted gold fiducial marker tracking, non-invasive stereotactic body immobilization.
Hypofractionated Carbon-Ion Radiotherapy (大分割碳离子放疗，通常仅需4-10次照射即可彻底消融大体积肝肿瘤).
Child-Pugh class A or well-compensated B (score ≤7); residual non-tumorous liver volume >30%; tumor diameter ≤15 cm; absence of macro-vascular portal vein main trunk occlusion and distant metastases.
Zhongshan Hospital, Fudan University (复旦大学附属中山医院)
Shanghai · National Medical Center (Liver Cancer Institute)World's highest-volume robotic liver resection suites, integrated microvascular interventional catheterization labs (TACE / HAIC), liver transplantation ICU.
Hepatic Arterial Infusion Chemotherapy (HAIC-FOLFOX) downstaging combined with Da Vinci Xi robotic radical liver resection.
BCLC stage B/C liver cancer with good hepatic reserve (ICG-15 <15%); ECOG score 0-1.
Locally Advanced Pancreatic Adenocarcinoma (局部晚期胰腺癌)
Target Stage & Goal: Borderline resectable or locally advanced pancreatic cancer with celiac axis or superior mesenteric artery/vein encasement without distant metastases.
Fudan University Shanghai Cancer Center (FUSCC) & SPHIC
Shanghai · National Cancer Clinical Center & Particle CenterSpecialized Pancreatic Cancer Institute, vascular reconstruction surgical theater, carbon-ion beam planning avoiding adjacent duodenal mucosa.
Neoadjuvant Carbon-Ion Radiation / Systemic Chemotherapy followed by Radical Pancreaticoduodenectomy (Whipple) with Mesenteric Vessel Reconstruction.
Pathologically confirmed adenocarcinoma; vascular contact without distant peritoneal seeding; CA19-9 verifiable; KPS score ≥80.
Recurrent High-Grade Glioma & Deep Brain Tumors (难治复发胶质母细胞瘤与颅内深部肿瘤)
Target Stage & Goal: Recurrent glioblastoma or refractory deep brain tumor after standard temozolomide chemoradiation requiring precision re-intervention.
Beijing Tiantan Hospital & SPHIC
Beijing / Shanghai · National Neurological Center & Particle FacilityNeurosurgical theaters equipped with intraoperative 3.0T MRI, 5-ALA fluorescence tumor visualization, neuronavigation, proton pencil beam scanning.
Fluorescence-Guided Maximum Safe Microsurgical Resection + Postoperative Focused Carbon-Ion/Proton Particle Boost.
Histologically verified recurrent high-grade glioma (WHO grade 3-4); KPS ≥60; localized recurrence with clear surgical or particle radiotherapy margins.
Gastrointestinal & Colorectal Peritoneal Carcinomatosis (晚期结直肠癌/胃癌腹膜转移)
Target Stage & Goal: Peritoneal surface dissemination from colorectal or gastric cancer with controlled systemic disease and low-to-moderate tumor burden.
Fudan University Shanghai Cancer Center & Ruijin Hospital
Shanghai · Grade 3A Public (National Cancer Clinical Centers)Specialized hyperthermic intraperitoneal chemotherapy (HIPEC) closed-loop perfusion machines, 4K 3D laparoscopic surgical theaters.
Cytoreductive Surgery (CRS) + Continuous Hyperthermic Intraperitoneal Chemotherapy (HIPEC) + Targeted Molecular Therapy.
Peritoneal Cancer Index (PCI) score ≤20; complete cytoreduction achievable (CC-0/1); no extra-abdominal metastases; ECOG 0-1.
Records Needed Before Clinical Review (5)
- ✓Complete radiation treatment plan reports: Total Gy, fractionation schedule, beam angles, and original DICOM RT dose files
- ✓All previous surgical pathology reports, immunohistochemistry (IHC) slides, and molecular genomic testing
- ✓Recent high-resolution contrast-enhanced MRI and PET-CT scans performed within 3 weeks (DICOM format)
- ✓Documentation of performance status (KPS / ECOG) and neurological deficit exam
- ✓Endoscopic reports and photos for head & neck or gastrointestinal lesions
Practical Pathway Financial Scope (4 stages)
Where expenses occur across the pathway · figures are published reference rangesScope: Expert radiation oncologist and surgeon review of previous RT dose distributions, DICOM scans, and eligibility confirmation.
Financial Notes: Consultation fee usually paid prior to formal admission; establishes whether carbon-ion or surgery is clinically viable.
Scope: Custom thermoplastic immobilization mask/mold, 4D respiratory-correlated CT, contrast MRI fusion, and physicist beam planning.
Financial Notes: Essential preparatory phase requiring 5-7 days before beam delivery starts.
Scope: Standard course of carbon-ion therapy (typically 12 to 24 fractions) or combined proton boost in specialized treatment gantry.
Financial Notes: SPHIC published standard particle radiotherapy course package is approximately 278,000 - 310,000 RMB for direct radiation.
Published reference range · noted 2026-08-18 · confirm current price
Scope: Inpatient room charges, mucosal protection, nutritional support, post-treatment verification MRI, and international follow-up schedule.
Financial Notes: Outpatient or inpatient accommodations around the center; total pathway budget should include 30-45 days local stay.
Published reference ranges noted 2026-08-18; they are not a quote. Confirm the current itemized price and payment terms directly with the hospital before budgeting or travel.
The fixed particle therapy package does not include preoperative systemic chemotherapy, special custom stents, complex vascular reconstruction, or extended ICU stays.
Published intake contacts — confirm before use
needs direct confirmationNo published international contact is recorded for this desk. Ask the candidate hospital's VIP or international center case by case.
Pre-Travel Clinical Intake Advisory
Pre-arrival record review, prior-radiation constraints, exclusion criteria, wait time, and itemized international-patient quote